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Abstract #1569

Fisher Information Matrix for Optimizing the Acquisition Parameters in Multi-Parametric Mapping Based on Fast Steady-State Sequences

romain valabregue1 and Ludovic De Rochefort2

1CENIR, ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127F, Paris, France, 2IR4M (Imagerie par Résonance Magnétique Médicale et Multi-modalités), Univ. Paris-Sud, CNRS, UMR8081, Université Paris-Saclay, Orsay, France

A criterion of A-optimality was used to optimize SSFP sequence acquisition parameters in order to perform multi-parametric mapping of the physical parameters proton density, relaxation rates and apparent diffusion coefficient. A fast calculation of the steady-state was used to estimate the Fisher information matrix from which fitted parameter error was determined from its inverse. Considering a range of possible T1 and T2 values, and relevant ADC, the acquisition parameters were optimized over the four dimensions of TR, prescribed flip angle, RF phase increment and spoiling gradient to achieve the minimum error on the effectively fitted physical parameters. It is demonstrated that choosing targeted T1 and T2 values over a wide range of expected values enables defining acquisition protocols that minimize the error over this range.

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