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Abstract #1571

Post-mortem reperfusion of the vascular system and examination in MRI: Temperature-dependent characterisation of perfusates and contrast simulations

Bridgette Webb1, Thomas Widek1, Bernhard Neumayer1, Rudolf Stollberger2, and Thorsten Schwark1,3

1Ludwig Boltzmann Institute for Clinical Forensic Imaging, Graz, Austria, 2Institute of Medical Engineering, Graz University of Technology, Graz, Austria, 3Institute of Legal Medicine, Medical University of Graz, Graz, Austria

MRI evaluation of a post-mortem reperfused cardiovascular system requires a complete filling of vessels, acceptable contrast/image quality and consideration of temperature influences. Assessment of the temperature dependence of viscosity, T1 and T2 of candidate perfusates (n=10) found 3 to be suitable for application in post-mortem MR angiography. Bloch equation simulations were applied to investigate contrast between these liquids and post-mortem myocardium at 1, 8.5, 16 and 23°C. For a FLASH sequence, optimal flip angles were affected by temperature variation and a decrease in contrast (max. 6-12%) was observed when flip angles optimised for one of the other temperatures were applied.

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