Abstract #1577

Short-term Evolution of Renal Metabolic Rate of Oxygen (RMRO2) in an Animal Model of acute intra-renal ischemia Using qBOLD and ASL MRI

Xiaodong Zhang¹, Yue Mi², Jing Wang³, Jingyun Wu¹, Rui Zhang⁴, Yan Sun¹, Xiaoying Wang^1,4, Jue Zhang⁴, and Hongyu An⁵

¹Department of Radiology, Peking University First Hospital, Beijing, China, People's Republic of, ²Department of Urology, Peking University First Hospital, Beijing, China, People's Republic of, ³Center for medical device evaluation, China Food and Drug Administration, Beijing, China, People's Republic of, ⁴Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, People's Republic of, ⁵Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Quantitative measurement of renal oxygen metabolism level is of central importance in understanding and treating renal diseases and renal metabolic rate of oxygen (RMRO2) can provide a valid criterion for evaluation the renal tissue oxygen metabolism level under both normal and disease states. According to the Fick principle of arteriovenous oxygen difference, the RMRO2 can be estimated by using a qBOLD and ASL technique. In this study, we will demonstrate the ability to obtain absolute quantitative RMRO2 noninvasively in normal and unilateral renal artery stenosis rabbits.

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