Abstract #1576

MRI-based Evaluation of Renal Oxygenation Under the Influence of Carbogen Breathing

Chengyan Wang¹, Rui Zhang², Li Jiang³, Rui Wang⁴, Xiaodong Zhang⁴, He Wang³, Kai Zhao⁴, Lixin Jin³, Jue Zhang^1,2, Xiaoying Wang^1,4, and Jing Fang^1,2

¹Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, People's Republic of, ²College of Engineering, Peking University, Beijing, China, People's Republic of, ³Philips Healthcare, Suzhou, China, People's Republic of, ⁴Department of Radiology, Peking University First Hospital, Beijing, China, People's Republic of

Renal oxygenation plays a major role in the evaluation of renal function and has attracted considerable attention in recent years. This study demonstrates the feasibility of using a susceptibility-based MRI technique for measuring renal oxygen extraction fraction (OEF) change under the influence of carbogen (97% O2, 3% CO2) breathing. Significant decrease of renal OEF was found during carbogen challenge. Furthermore, the efficacy of this susceptibility-based method was proved by blood pO2 measurement.

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