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Abstract #1576

MRI-based Evaluation of Renal Oxygenation Under the Influence of Carbogen Breathing

Chengyan Wang1, Rui Zhang2, Li Jiang3, Rui Wang4, Xiaodong Zhang4, He Wang3, Kai Zhao4, Lixin Jin3, Jue Zhang1,2, Xiaoying Wang1,4, and Jing Fang1,2

1Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, People's Republic of, 2College of Engineering, Peking University, Beijing, China, People's Republic of, 3Philips Healthcare, Suzhou, China, People's Republic of, 4Department of Radiology, Peking University First Hospital, Beijing, China, People's Republic of

Renal oxygenation plays a major role in the evaluation of renal function and has attracted considerable attention in recent years. This study demonstrates the feasibility of using a susceptibility-based MRI technique for measuring renal oxygen extraction fraction (OEF) change under the influence of carbogen (97% O2, 3% CO2) breathing. Significant decrease of renal OEF was found during carbogen challenge. Furthermore, the efficacy of this susceptibility-based method was proved by blood pO2 measurement.

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