Abstract #1575

Assessment of Physiological Changes Associated with Renal Fibrosis in a Rat Model

Lei Jiang¹, Paul Territo¹, Brian McCarthy¹, Amanda A. Riley¹, Sourajit Mustafi¹, Yu-Chien Wu¹, Bruce Molitoris², Gary Hutchins¹, and Chen Lin¹

¹Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ²Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States

The objective of this study is to evaluate the capability of quantitative MRI techniques to measure physiological changes associated with changes in renal function in a rat model. Our investigation suggest that the results of T₂* mapping, intra-voxel incoherent motion (IVIM), and T1ρ imaging are comparable to the published results. These techniques can be used to assess and monitor different aspects of physiological changes in kidney fibrosis.

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