Abstract #1574

Detection and Analysis of Renal Cortical and Medullary T2* Heterogeneity with Minkowski Functionals

Sabrina Klix¹, Andreas Pohlmann¹, Jan Hentschel¹, Karen Arakelyan^1,2, Mandy Fechner³, Kathleen Cantow², Bert Flemming², Sonia Waiczies¹, Erdmann Seeliger², and Thoralf Niendorf^1,4

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, Germany, ²Institute of Physiology, Charité Universitaetsmedizin, Berlin, Germany, ³Nephrology and Intensive Care Medicine, Campus Virchow-Klinikum and Center for Cardiovascular Research, Charite-Universitaetsmedizin Berlin, Berlin, Germany, ⁴Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrueck Center for Molecular Medicince, Berlin, Germany

Minkowski Functionals (MFs) allow a quantitative analysis of tissue heterogeneity – independent of absolute values, which can be biased by magnetic field strength, B₀ homogeneity, voxel size, etc. Here we applied this technique to characterize renal cortical and medullary T₂^* heterogeneity in order to test the feasibility of a differentiation between healthy kidneys, and kidney injuries.

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