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Abstract #1574

Detection and Analysis of Renal Cortical and Medullary T2* Heterogeneity with Minkowski Functionals

Sabrina Klix1, Andreas Pohlmann1, Jan Hentschel1, Karen Arakelyan1,2, Mandy Fechner3, Kathleen Cantow2, Bert Flemming2, Sonia Waiczies1, Erdmann Seeliger2, and Thoralf Niendorf1,4

1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, Germany, 2Institute of Physiology, Charité Universitaetsmedizin, Berlin, Germany, 3Nephrology and Intensive Care Medicine, Campus Virchow-Klinikum and Center for Cardiovascular Research, Charite-Universitaetsmedizin Berlin, Berlin, Germany, 4Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrueck Center for Molecular Medicince, Berlin, Germany

Minkowski Functionals (MFs) allow a quantitative analysis of tissue heterogeneity – independent of absolute values, which can be biased by magnetic field strength, B0 homogeneity, voxel size, etc. Here we applied this technique to characterize renal cortical and medullary T2* heterogeneity in order to test the feasibility of a differentiation between healthy kidneys, and kidney injuries.

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