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Abstract #1610

Quantitative Aerosol Deposition in Mechanically-Ventilated Healthy and Asthmatic Rats using UTE-MRI

Hongchen Wang1, Georges Willoquet1, Catherine Sebrié1, Sébastien Judé2, Anne Maurin2, Rose-Marie Dubuisson1, Luc Darrasse1, Geneviève Guillot1, Ludovic de Rochefort1, and Xavier Maître1

1Imagerie par Résonance Magnétique Médicale et Multi-Modalités (UMR8081) IR4M, CNRS, Univ. Paris-Sud, Orsay, France, 2Centre de Recherches Biologiques, CERB, Baugy, France

Asthma is the most common chronic respiratory disease treated with inhaled therapy. However, aerosol deposition patterns are complex and imaging methods are needed to improve delivery efficiency. 3D UTE-MRI combined with aerosolized Gd-DOTA had been formerly applied onto spontaneous nose-only-breathing animals. Here, a mechanical administration system was developed to ventilate and nebulize rats. Resulting aerosol distribution and kinetics were compared with free-breathing in healthy and asthmatic animals.

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