Abstract #1611

Investigation of the Multiple T2* Compartments in Lung Parenchyma using a 3D Multi-Echo Radial sequence

Aiming Lu¹, Xiangzhi Zhou¹, Mitsue Miyazaki¹, Masao Yui², Masaaki Umeda², and Yoshiharu Ohno^3,4

¹Toshiba Medical Research Inst., Vernon Hills, IL, United States, ²Toshiba Medical System Corp, Otawara, Japan, ³Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Japan, ⁴Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan

T2* mapping with a single-exponential model have been demonstrated to be useful in accessing pulmonary functional loss. However, the model does not fully explain the signal evolution at longer TEs. We propose to improve the T2* characterization in the lung parenchyma with a bi-exponential model. Using a 3D multi-echo radial sequence, our results demonstrated that short T2* values and the volume fractions of the two compartments could be obtained on a clinical 3T scanner. In addition to the improved accuracy of the short T2* measurement, the added fraction values could also potentially be used as biomarkers.

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