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Abstract #1612

T1 relaxation time in lungs of asymptomatic smokers

Daniel Alamidi1, Simon Kindvall2, Penny Hubbard Cristinacce3, Deirdre McGrath3, Simon Young4, Josephine Naish3, John Waterton3, Per Wollmer5, Sandra Diaz5, Marita Olsson6, Paul Hockings7,8, Kerstin Lagerstrand1, Geoffrey Parker3,9, and Lars E Olsson2

1Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 2Department of Medical Physics, Lund University, Translational Sciences, Malmö, Sweden, 3Centre for Imaging Sciences and Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom, 4AstraZeneca R&D, Alderley Park, United Kingdom, 5Department of Translational Medicine, Lund University, Malmö, Sweden, 6AstraZeneca R&D, Mölndal, Sweden, 7Medtech West, Chalmers University of Technology, Gothenburg, Sweden, 8Antaros Medical, BioVenture Hub, Mölndal, Sweden, 9Bioxydyn Ltd, Manchester, United Kingdom

Tobacco smoking is the primary cause of COPD. MRI may improve the characterization of COPD where T1 of the lungs is a potential biomarker. We investigated whether smoking affects lung T1 in individuals with no known lung disease. Lung T1 measurements were performed in asymptomatic current and never smokers. T1 was shortened with age and an indication of shortened T1 in smokers was observed that most likely reflects early signs of smoking-induced lung pathology. Our results may be of utility to power future prospective studies with larger cohorts and improved regional analysis.

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