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Abstract #1614

Asymmetric line broadening in lung tissue

Lukas Reinhold Buschle1, Felix Tobias Kurz1,2, Thomas Kampf3, Heinz-Peter Schlemmer1, and Christian Herbert Ziener1

1E010 Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany, 3Department of Experimental Physics 5, University of W├╝rzburg, W├╝rzburg, Germany

We analyze the local line shape in human lung tissue in dependence of the underlying microscopic tissue parameters such as diffusion coefficient, alveolar size and susceptibility difference. The interplay between susceptibility- and diffusion-mediated effects is discussed in several dephasing regimes. In vivo measurements for human lung tissue show an excellent agreement with simulations of the dephasing process. This allows an improved quantitative diagnosis of early pulmonary fibrosis and emphysema.

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