Abstract #1615

Dephasing and diffusion on the alveolar surface

Lukas Reinhold Buschle¹, Felix Tobias Kurz^1,2, Thomas Kampf³, Heinz-Peter Schlemmer¹, and Christian Herbert Ziener¹

¹E010 Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany, ³Department of Experimental Physics 5, University of Würzburg, Würzburg, Germany

In lung tissue, the susceptibility difference between air-filled alveoli and surrounding tissue causes a strong dephasing of spin-bearing particles. The particles experience an averaged magnetic field due to diffusion effects. Thus, the dephasing process slows down. Both diffusion and susceptibility effects are described by the Bloch-Torrey equation that is solved for the local magnetization on the surface of alveoli. The analytical solution of the free induction decay is compared to in vivo measurements in human lung tissue.

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