Investigating the Correlation between Alveolar Surface-to-Volume Ratio and Apparent Diffusion Coefficient with Hyperpolarized Xenon-129 MRI
Kai Ruppert1,2, Kun Qing2, Talissa A. Altes2,3, and John P. Mugler III2
1Cincinnati Children's Hospital, Cincinnati, OH, United States, 2University of Virginia, Charlottesville, VA, United States, 3University of Missouri, Columbia, MO, United States
Chemical Shift Saturation Recovery (CSSR) MR Spectroscopy is a method for monitoring the uptake of hyperpolarized xenon-129 (HXe) by lung parenchyma. The purpose of this study was to investigate the correlation between the alveolar surface-to-volume ratio (S/V) as assessed by CSSR spectroscopy and apparent diffusion coefficient measurements in subjects with chronic-obstructive pulmonary disease, healthy smokers and age-matched normals. Only for very short delay times (5 ms or less) a good correlation was established. Surprisingly, the best correlation, and presumably most accurate S/V value, was obtained by using just the red-blood cell peak at the shortest measured delay time of 3ms.
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