Abstract #1620

Investigating the Correlation between Alveolar Surface-to-Volume Ratio and Apparent Diffusion Coefficient with Hyperpolarized Xenon-129 MRI

Kai Ruppert^1,2, Kun Qing², Talissa A. Altes^2,3, and John P. Mugler III²

¹Cincinnati Children's Hospital, Cincinnati, OH, United States, ²University of Virginia, Charlottesville, VA, United States, ³University of Missouri, Columbia, MO, United States

Chemical Shift Saturation Recovery (CSSR) MR Spectroscopy is a method for monitoring the uptake of hyperpolarized xenon-129 (HXe) by lung parenchyma. The purpose of this study was to investigate the correlation between the alveolar surface-to-volume ratio (S/V) as assessed by CSSR spectroscopy and apparent diffusion coefficient measurements in subjects with chronic-obstructive pulmonary disease, healthy smokers and age-matched normals. Only for very short delay times (5 ms or less) a good correlation was established. Surprisingly, the best correlation, and presumably most accurate S/V value, was obtained by using just the red-blood cell peak at the shortest measured delay time of 3ms.

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