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Abstract #1621

Hyperpolarized Xenon-129 Lung 3D SB-CSI at 1.5 and 3 Tesla

Steven Guan1, Kun Qing1, Talissa Altes1, John Mugler III1, Borna Mehrad1, Michael Shim1, Quan Chen1, Paul Read1, James Larner1, Iulian Ruset2,3, Grady Miller1, James Brookeman1, William Hersman2,3, and Jaime Mata1

1University of Virginia, Charlottesville, VA, United States, 2University of New Hampshire, Duhram, NH, United States, 3XeMed, Duhram, NH, United States

3D Single-Breath Chemical Shift Imaging (3D SB-CSI) is capable of non-invasively assessing regional lung ventilation and gas uptake/exchange within a single breath-hold, typically less than 13 seconds. From this study, we present preliminary clinical results of 3D SB-CSI from healthy, cystic fibrosis (CF), interstitial lung disease (ILD), and lung cancer (LC) subjects at 1.5T and 3T. Having novel information on regional changes in ventilation and gas uptake/exchange allows for a better understanding of lung physiology, disease progression, and treatment efficacy.

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