Abstract #1625

Lobar Ventilation Heterogeneity in Asthma and Cystic Fibrosis Assessed with Hyperpolarized Helium-3 MRI and Computed Tomography

Wei Zha¹, Jeffery N Kammerman¹, David G Mummy², Alfonso Rodriguez¹, Robert V Cadman¹, Scott K Nagle^1,3,4, Ronald L Sorkness^4,5,6, and Sean B Fain^1,2,3

¹Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ³Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁴Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, United States, ⁵Medicine-Allergy, Pulmonary & Critical Care, University of Wisconsin-Madison, Madison, WI, United States, ⁶Pharmacy, University of Wisconsin-Madison, Madison, WI, United States

Seven cystic fibrosis (CF) and 69 asthma subjects with different severities of disease underwent hyperpolarized helium-3 MRI and multidetector computed tomography (MDCT). Lobar segmentation was performed on proton MRI by referencing corresponding MDCT. The lobar ventilation defect percent (VDP) was measured by adaptive K-means. Pairwise comparison showed that lobar VDP variation patterns were different in CF vs. asthma, although patterns were similar in severe vs. non-severe asthma. Disease-related lobar VDP variation patterns may provide a sensitive indicator for early detection and patterns of progression in obstructive lung disease.

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