Abstract #1626

Severity Evaluation in Cystic Fibrosis Using Oxygen-enhanced MRI: Comparison to Hyperpolarized Helium-3 MRI

Wei Zha¹, Stanley J Kruger¹, Robert V Cadman¹, Kevin M Johnson^1,2, Andrew D Hahn¹, Scott K Nagle^1,2,3, and Sean B Fain^1,2,4

¹Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States

Oxygen-enhanced MRI using 3D radial ultrashort echo time sequence (OE-MRI) is a promising alternative to evaluate ventilation and defects with wider accessibility and better affordability. Eleven cystic fibrosis (CF) subjects with different severities of disease underwent OE-MRI and HP-MRI. The disease severity ranks on the percent signal enhancement map (PSE) derived from OE-MRI was compared to the whole lung ventilation defect percent (VDP) measured from HP-MRI as a reference standard using Spearman rank correlation. The moderate association between VDP and PSE suggest OE-MRI shows promise for differentiating disease severity in CF.

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