Abstract #1628

Quantitative Gas Exchange using Hyperpolarized 129Xe MRI in Idiopathic Pulmonary Fibrosis

Ziyi Wang¹, Scott Haile Robertson², Jennifer Wang³, Elianna Ada Bier², Mu He⁴, and Bastiaan Driehuys^1,2,5

¹Biomedical Engineering, Duke University, Durham, NC, United States, ²Medical Physics Graduate Program, Duke University, Durham, NC, United States, ³School of Medicine, Duke University, Durham, NC, United States, ⁴Electrical and Computer Engineering, Duke University, Durham, NC, United States, ⁵Radiology, Duke University Medical Center, Durham, NC, United States

Hyperpolarized ¹²⁹Xe MRI exploits solubility and chemical shift to image regional alterations in gas exchange. These properties have been particularly promising for sensitive detection and monitoring of idiopathic pulmonary fibrosis (IPF). Here we seek to refine our analysis of regional gas exchange impairment by mapping the ¹²⁹Xe uptake in blood and barrier tissues relative to gas-phase signal intensity. This work shows that gas exchange impairment is dominated by increased ¹²⁹Xe uptake in barrier tissues.

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