Abstract #1629

In situ pH effects within Mycobacterium tuberculosis Infected Mice revealed by UTE-CEST MRI

Jiadi Xu¹, Vincent DeMarco², Supriya Pokkali ², Alvaro Ordonez², Mariah Klunk², Marie-France Penet³, Zaver Bhujwalla³, Peter van Zijl^1,3, and Sanjay Jain^2,4

¹F. M. Kirby Center, kennedy Krieger Institute, Baltimore, MD, United States, ²Center for Infection and Inflammation Imaging Research, Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States

A UTE-CEST scheme was developed to acquire CEST spectrum on M. Tuberculosis lesions in mouse lung. The scheme repeats a selective saturation pulse together with an appropriate mixing time; MRI images are acquired using the UTE technique during the mixing times. The UTE readout is able to suppress the respiratory motion artifacts commonly seen in lung MRI. The pattern of the MTRasym spectra in the TB lesion, which is dominated by protein signals, was used to assess lesion pH.

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