Abstract #1642

Effect of Betaine on Intrahepatic Triglyceride Levels: Reproducibility and Preliminary Results

Adrienne Lee¹, Benjamin Rowland¹, Huijun Liao¹, Ana Maria Grizales², Allison Goldfine², and Alexander Lin¹

¹Center for Clinical Spectroscopy, Brigham and Women’s Hospital, Boston, MA, United States, ²Research Division, Joslin Diabetes Center, Boston, MA, United States

Proton magnetic resonance spectroscopy (MRS) is an accurate, noninvasive method used to monitor intrahepatic triglyceride (IHTG) levels in four patients undergoing betaine treatment for nonalcoholic fatty liver disease (NAFLD). Comparison of results in two of the patients with lower IHTG levels at baseline showed a decrease or improvement after betaine supplementation. However, two subjects with baseline elevated levels of IHTG did not show an improvement and in fact showed higher IHTG levels. Reproducibility of primary lipid vs secondary lipid measurements were also obtained and demonstrated high and low reproducibility, respectively.

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