Meeting Banner
Abstract #1642

Effect of Betaine on Intrahepatic Triglyceride Levels: Reproducibility and Preliminary Results

Adrienne Lee1, Benjamin Rowland1, Huijun Liao1, Ana Maria Grizales2, Allison Goldfine2, and Alexander Lin1

1Center for Clinical Spectroscopy, Brigham and Women’s Hospital, Boston, MA, United States, 2Research Division, Joslin Diabetes Center, Boston, MA, United States

Proton magnetic resonance spectroscopy (MRS) is an accurate, noninvasive method used to monitor intrahepatic triglyceride (IHTG) levels in four patients undergoing betaine treatment for nonalcoholic fatty liver disease (NAFLD). Comparison of results in two of the patients with lower IHTG levels at baseline showed a decrease or improvement after betaine supplementation. However, two subjects with baseline elevated levels of IHTG did not show an improvement and in fact showed higher IHTG levels. Reproducibility of primary lipid vs secondary lipid measurements were also obtained and demonstrated high and low reproducibility, respectively.

This abstract and the presentation materials are available to members only; a login is required.

Join Here