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Abstract #1653

Frontal-parietal network functional connectivity characterization in patients with end-stage renal disease by using independent component analysis

Lin Wang1, Chun-Qiang Lu1, and Shenghong Ju1

1Department of Radiology, Zhongda hospital, Medical school of Southeast university, Nanjing, China, People's Republic of

It has been reported that end-stage renal disease (ESRD) patients have cognitive decline in all aspects, especially in attention and executive function, and this is lack of objective noninvasive modalities to monitor the cognition impairment by now. Resting-stage functional MR which can detect the change of brain function as a newly-developing imaging method has been widely used to evaluate the cognitive status in many diseases. Our findings show the aberrant functional connectivity of frontal-parietal network (FPN) in ESRD patients, and supported by the results of neuropsychological tests. FPN functional connectivity may serve as a biomarker to monitor the attention and executive function impairment in patients with ESRD in the future.

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