Abstract #1652

A Robust Anesthesia Regime for fMRI in Rodents

Hanbing Lu¹, Julie Brynildsen¹, Li-Ming Hsu¹, Thomas Ross¹, Elliot A Stein¹, and Yihong Yang¹

¹Neuroimaging Research Branch, National Institute on Drug Abuse, NIH, Baltimore, MD, United States

In fMRI using animal models, it is of critical importance to develop a robust anesthetic regime that maintains neurovascular coupling, permits longitudinal experiments with minimal invasiveness, and is easy to implement. Recently, using an anesthetic method that combines low doses of dexmedetomidine and low dose of isoflurane, we have successfully identified the default mode network in rat brain, suggesting that this preparation causes minimal suppression of brain network functions. The goal of this study is to systematically characterize and to optimize physiological conditions for fMRI experiments under this anesthetic regime.

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