Md Taufiq Nasseef1,2, Adam Liska1,2, Stefano Panzeri1, and Alessandro Gozzi1
1Italian Institute of Technology,Center for Neuroscience and Cognitive Systems @UniTn, Rovereto, Italy, 2Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy
Mouse resting-state fMRI (rsfMRI) has revealed the presence
of distributed functional connectivity networks including two
sets of regions exhibiting neuro-anatomical features reminiscent of the human
salience (SN) and default-mode-network (DMN).
Here, we applied Granger Causality to investigate the direction of information
flow within mouse rsfMRI networks characterized by mono-directional and
reciprocal underlying axonal connectivity. We show that multiple intrinsic
rsfMRI networks of the mouse brain exhibit robust patterns of directional
connectivity towards prefrontal regions, replicating topological features of
human rsfMRI networks, and in agreement with higher integrative role subserved
by these areas.