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Abstract #1651

Directional connectivity in mouse fMRI networks

Md Taufiq Nasseef1,2, Adam Liska1,2, Stefano Panzeri1, and Alessandro Gozzi1

1Italian Institute of Technology,Center for Neuroscience and Cognitive Systems @UniTn, Rovereto, Italy, 2Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy

Mouse resting-state fMRI (rsfMRI) has revealed the presence of distributed functional connectivity networks including two sets of regions exhibiting neuro-anatomical features reminiscent of the human salience (SN) and default-mode-network (DMN). Here, we applied Granger Causality to investigate the direction of information flow within mouse rsfMRI networks characterized by mono-directional and reciprocal underlying axonal connectivity. We show that multiple intrinsic rsfMRI networks of the mouse brain exhibit robust patterns of directional connectivity towards prefrontal regions, replicating topological features of human rsfMRI networks, and in agreement with higher integrative role subserved by these areas.

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