Abstract #1659

Condition effects on resting-state CBF reproducibility and reliability

Marta Vidorreta^1,2, Natalie N Katchmar³, Daniel H Wolf³, and John A Detre^1,2

¹Neurology, University of Pennsylvania, Philadelphia, PA, United States, ²Radiology, University of Pennsylvania, Philadelphia, PA, United States, ³Psychiatry, University of Pennsylvania, Philadelphia, PA, United States

Cerebral blood flow (CBF) data were collected with arterial spin labeled (ASL) perfusion MRI in a group of young, healthy subjects over two sessions, scheduled a week apart. CBF and functional connectivity metrics were derived from the CBF time series across four different resting conditions: ‘eyes open’, ‘eyes closed’, ‘fixation’ (eyes fixated on a cross), and ‘PVT’ (low-frequency psychomotor vigilance task). Absolute CBF was highly reproducible both within and across sessions. Results suggest that ‘fixation’ is inferior to the other conditions tested for resting-state ASL reproducibility.

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