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Abstract #1660

Title: Distinctive relationships between functional and structural connectivity in autism spectrum disorder across different networks— a combined resting-state functional MRI and diffusion spectrum imaging study

Hsiang-Yun Sherry Chien1, Susan Shur-Fen Gau2, and Wen-Yih Isaac Tseng1,3

1Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, Taipei, Taiwan, 2Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, Taipei, Taiwan, 3Molecular Imaging Center, National Taiwan University, Taipei, Taiwan, Taipei, Taiwan

We conducted a data-driven approach to investigate the functional and structural connectivity (FC and SC) within three critical networks in autism spectrum disorder (ASD) and typically developing controls (TD). We found significant weaker SC within the default-mode network, e.g. the cingulum bundles, in ASD compared to TD. Furthermore, we found significant positive correlations between the FC of the right salience network and the SC within the DMN and central executive network (CEN). Given the role of salience network in modulating the switch between the DMN and CEN, our results might imply a distinctive FC-SC relationship across different networks in ASD.

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