1MR Research China, GE Healthcare, Beijing, China, People's Republic of, 2Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, People's Republic of, 3GE Healthcare, Menlo Park, CA, United States
This preliminary study investigated
functional connectivity changes in Alzheimer’s Disease (AD) and amnestic
mild cognitive impairment (MCI) using degree centrality (DC), a novel
resting-state fMRI parameter to provide voxel-wise whole brain functional
connectivity measurement. Twelve AD patients, twelve MCI patients and fifteen
healthy controls were recruited for comparison. As compared to normal controls,
AD patients showed the deceased DC in the posterior cingulate cortex while MCI
patients showed decreased DC in bilateral cuneus (visual processing) but
increased DC in bilateral hippocampus (memory) and right angular gyrus
(language). The different patterns of FC
changes might provide insight into disease evolvement.
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