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Abstract #1684

Investigation of functional connectivity changes in Alzheimer's disease and amnestic mild cognitive impairment using Degree Centrality

Yong Zhang1, Naying He2, Hua-Wei Lin2, Ajit Shankaranarayanan3, Zhenyu Zhou1, and Fu-Hua Yan2

1MR Research China, GE Healthcare, Beijing, China, People's Republic of, 2Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, People's Republic of, 3GE Healthcare, Menlo Park, CA, United States

This preliminary study investigated functional connectivity changes in Alzheimer’s Disease (AD) and amnestic mild cognitive impairment (MCI) using degree centrality (DC), a novel resting-state fMRI parameter to provide voxel-wise whole brain functional connectivity measurement. Twelve AD patients, twelve MCI patients and fifteen healthy controls were recruited for comparison. As compared to normal controls, AD patients showed the deceased DC in the posterior cingulate cortex while MCI patients showed decreased DC in bilateral cuneus (visual processing) but increased DC in bilateral hippocampus (memory) and right angular gyrus (language). The different patterns of FC changes might provide insight into disease evolvement.

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