Abstract #1684

Investigation of functional connectivity changes in Alzheimer's disease and amnestic mild cognitive impairment using Degree Centrality

Yong Zhang¹, Naying He², Hua-Wei Lin², Ajit Shankaranarayanan³, Zhenyu Zhou¹, and Fu-Hua Yan²

¹MR Research China, GE Healthcare, Beijing, China, People's Republic of, ²Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, People's Republic of, ³GE Healthcare, Menlo Park, CA, United States

This preliminary study investigated functional connectivity changes in Alzheimer’s Disease (AD) and amnestic mild cognitive impairment (MCI) using degree centrality (DC), a novel resting-state fMRI parameter to provide voxel-wise whole brain functional connectivity measurement. Twelve AD patients, twelve MCI patients and fifteen healthy controls were recruited for comparison. As compared to normal controls, AD patients showed the deceased DC in the posterior cingulate cortex while MCI patients showed decreased DC in bilateral cuneus (visual processing) but increased DC in bilateral hippocampus (memory) and right angular gyrus (language). The different patterns of FC changes might provide insight into disease evolvement.

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