Ebola Alters Some, But Not All, Resting-State Intrinsic Functional Connectivity Networks In The Macaque Brain
Eswar Damaraju1, Margaret Lentz2, Jeffrey David Lewine1,3, David Thomasson2, Nadia Biassou4, Anna Honko2, Vince Calhoun1, and Peter Jahrling2
1Mind Research Network, Albuquerque, NM, United States, 2Integrated Research Facility/NIAID, Frederick, MD, United States, 3Lovelace Family of Companies, Albuquerque, NM, United States, 4NIH Clinical Center, Bethesda, MD, United States
Ebola has the potential to cause both acute and chronic
compromise of neurological status. To
better understand the relevant neurobiology, a pilot MRI study of infected
macaques was performed. Data indicate
that Ebola exposure leads to acute disruption of some, but not all, intrinsic
connectivity networks, even in the absence of intraparenchymal lesions. These studies represent the first
non-invasive functional imaging studies of living, Ebola infected non-human
primates.
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