Abstract #1685

Ebola Alters Some, But Not All, Resting-State Intrinsic Functional Connectivity Networks In The Macaque Brain

Eswar Damaraju¹, Margaret Lentz², Jeffrey David Lewine^1,3, David Thomasson², Nadia Biassou⁴, Anna Honko², Vince Calhoun¹, and Peter Jahrling²

¹Mind Research Network, Albuquerque, NM, United States, ²Integrated Research Facility/NIAID, Frederick, MD, United States, ³Lovelace Family of Companies, Albuquerque, NM, United States, ⁴NIH Clinical Center, Bethesda, MD, United States

Ebola has the potential to cause both acute and chronic compromise of neurological status. To better understand the relevant neurobiology, a pilot MRI study of infected macaques was performed. Data indicate that Ebola exposure leads to acute disruption of some, but not all, intrinsic connectivity networks, even in the absence of intraparenchymal lesions. These studies represent the first non-invasive functional imaging studies of living, Ebola infected non-human primates.

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