Abstract #1694

Can Cerebral Functional Deficits Be Detected in Patients with Ankylosing Spondylitis?- A Cross-sectional Study

Jun Zhao¹, Chuan-Ming Li¹, Xin Wei¹, and Jian Wang¹

¹Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China, People's Republic of

This study aimed to investigate any cerebral function deficits in AS(Ankylosing spondylitis) using functional MRI technology and its possible relationship to clinical and laboratory results. Compared with normal controls, AS patients showed widespread brain activity and connectivity alterations. Functional connectivity strength of the left precuneus and the left middle temporal gyrus were closely correlated with the the BASDAI scores, ESR and hsCRP in AS patients. AS is associated with a altered cortical activity of rs-fMRI signals. Measurement of functional connectivity strength of the left precuneus and the left middle temporal gyrus may aid in the clinical detection and evaluation of AS

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