Abstract #1695

Functional dysconnection between anterior cingulate cortex and thalamus in patients with Kleine-Levin syndrome

Ting-Chih Wang¹, Yao-Chia Shih^2,3, Hong-Huei Liu⁴, and Wen-Yih Issac Tseng^3,5

¹Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, ²Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, ³Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ⁴Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan, ⁵Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

Kleine-Levin Syndrome is a rare neurological disorder characterized by recurrent episodes of excessive sleepiness and other symptoms listed in the ICSD Diagnostic Criteria for KLS. Its etiology is still unknown nowadays. The most consistent finding in KLS is abnormal thalamic function. Here, we used seed-based analysis to analyze resting state fMRI obtained from 2 patients with KLS. In bilateral thalamic seeding, both patients showed decreased connection between the thalamus and the anterior cingulate cortex. This result could be attributed to alteration of the dorsal pathway in ascending arousal system, and might also explain their attention deficits.

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