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Abstract #1697

Functional connectivity changes in attention-related networks of childhood leukemia survivors

Charlotte Sleurs1, Iris Elens2, Jurgen Lemiere1, Thibo Billiet3, Dorothée Vercruysse4, Patricia Bijttebier5, Marina Danckaerts2, Rudi D'Hooghe6, Ron Peeters3, Stefan Sunaert3, Anne Uyttebroeck1, Stefaan Van Gool7, and Sabine Deprez3

1Pediatric Hemato-Oncology, UZ Leuven, Leuven, Belgium, 2Child and Adolescent Psychiatry, UZ Leuven, Leuven, Belgium, 3Radiology, UZ Leuven, Leuven, Belgium, 4Gynaecological Oncology, UZ Leuven, Leuven, Belgium, 5School Psychology and Child and Adolescent Development, KU Leuven, Leuven, Belgium, 6Biological Psychology, KU Leuven, Leuven, Belgium, 7Pediatric Hemato-Oncology, University Hospital, Aachen, Germany

Neurocognitive sequelae in childhood leukemia survivors are often related to attentional disfunctioning. We investigated whether altered functional brain connectivity might explain neurocognitive sequelae in childhood leukemia survivors. Resting state fMRI was investigated, by using ROI-based connectivity comparisons as well as dual regression analysis at whole-brain level. We demonstrated that the Default Mode Network (DMN) and Inferior Temporal Gyrus, was less functionally connected in childhood leukemia survivors compared to controls. This suggests an altered coherence between activity of the DMN and Fronto-Parietal Network (FPN). Finally, based on this specific connectivity we could predict clearly reduced cognitive flexibility of the patients.

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