Effects of long-duration isoflurane administration on default mode network of macaque brains
Chun-Xia Li1 and Xiaodong Zhang1,2
1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 2Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate, Atlanta, GA, United States
Long-duration anesthesia administration
could cause neurocognitive decline in animals and humans. However, the
potential mechanism still remains unclear. In the present study, the functional
connectivity of adult rhesus monkeys under maintenance dosage of isoflurane (~1
%) for four hours was examined. The
results demonstrate that long-duration isoflurane exposure resulted in decreased functional connectivity in
posterior cingulate cortex (PCC)
dominant default-mode network (DMN).
The MRI findings suggest that the detrimental effects of isoflurane on brain
connectivity may be associated with the neurocognitive decline observed in subjects after
long-duration administration of isoflurane.
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