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Abstract #1698

Effects of long-duration isoflurane administration on default mode network of macaque brains

Chun-Xia Li1 and Xiaodong Zhang1,2

1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 2Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate, Atlanta, GA, United States

Long-duration anesthesia administration could cause neurocognitive decline in animals and humans. However, the potential mechanism still remains unclear. In the present study, the functional connectivity of adult rhesus monkeys under maintenance dosage of isoflurane (~1 %) for four hours was examined. The results demonstrate that long-duration isoflurane exposure resulted in decreased functional connectivity in posterior cingulate cortex (PCC) dominant default-mode network (DMN). The MRI findings suggest that the detrimental effects of isoflurane on brain connectivity may be associated with the neurocognitive decline observed in subjects after long-duration administration of isoflurane.

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