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Abstract #1704

Putamen-related regional and network functional deficits in first-episode schizophrenia with auditory verbal hallucinations

Long-Biao Cui1, Yi-Bin Xi1, and Hong Yin1

1Xijing Hospital, Fourth Mililtary Medical University, Xi'an, China, People's Republic of

Our results suggest an association of abnormal regional function in the putamen and prefrontal cortex and hyperconnectivity between them with AVHs in SZ. The functional interaction of the putamen with DLPFC and Broca’s area seems to be crucial for AVHs in SZ. Additionally, the putamen-related regional and network functional deficits may also serve as a potential diagnostic biomarker of AVHs in SZ based on the direct evidence in vivo we found. In SZ patients, there is an extensive hypoconnectivity within cortical-striatal-cerebellar networks, which further supports the current thinking about disconnection hypothesis of SZ.

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