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Abstract #1706

Visual Networks Impairments in Minimal Hepatic Encephalopathy Using Resting-State fMRI

Yun Jiao1, Xun-Heng Wang2, and Tian-Yun Tang1

1Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical school of Southeast University, Nanjing, China, People's Republic of, 2College of Life Information Science and Instrument Engineering, Hangzhou Dianzi University, Hangzhou, China, People's Republic of

We applied dual regression to investigated functional connectivity impairments within visual networks for minimal hepatic encephalopathy (MHE) patients’ brain. Functional deficits within occipital and lateral visual networks (visual area V2 and V3) were endogenous, and significantly association with neurocognitive impairments. This maybe the reason for the compensatory enhancements within medial visual network (visual area V1) which indicated that patients with MHE had the potential to additionally recruit more neurological resource to process the spatial information from visual areas V2 and V3. Our results demonstrated the possible mechanisms for deficits in visual perception, visuo-spatial orientation, and visuo-constructive abilities in MHE patients

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