Abstract #1714

Flow-diffusion constrained estimation of oxygen extraction fraction and tissue oxygen tension by dual calibrated fMRI

Michael Germuska¹, Alberto Merola¹, and Richard G Wise¹

¹CUBRIC, Cardiff University, Cardiff, United Kingdom

An emerging method for quantitative mapping of OEF is by dual calibration of the BOLD signal. ^1,2 However, this method is highly sensitive to measurement noise, resulting in unstable estimates of OEF. An alternative approach is to use flow-diffusion equations to calculate the biophysically supported OEF. ³ However, this approach is limited by the need to assume a tissue oxygen tension (PtO₂). We propose a method for combining these two approaches, producing calibrated BOLD estimates of OEF that are constrained by a modelled flow-diffusion relationship of oxygen extraction. The proposed method is shown to produce stable estimates of OEF and PtO₂.

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