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Abstract #1714

Flow-diffusion constrained estimation of oxygen extraction fraction and tissue oxygen tension by dual calibrated fMRI

Michael Germuska1, Alberto Merola1, and Richard G Wise1

1CUBRIC, Cardiff University, Cardiff, United Kingdom

An emerging method for quantitative mapping of OEF is by dual calibration of the BOLD signal. 1,2 However, this method is highly sensitive to measurement noise, resulting in unstable estimates of OEF. An alternative approach is to use flow-diffusion equations to calculate the biophysically supported OEF. 3 However, this approach is limited by the need to assume a tissue oxygen tension (PtO2). We propose a method for combining these two approaches, producing calibrated BOLD estimates of OEF that are constrained by a modelled flow-diffusion relationship of oxygen extraction. The proposed method is shown to produce stable estimates of OEF and PtO2.

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