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Abstract #1715

Do human cerebral arteries contain fully oxygenated blood?

Esther AH Warnert1, Ian D Driver1, Joseph Whittaker1, and Kevin Murphy1

1Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom

When modelling the BOLD response it is often assumed that arterial blood is fully oxygenated, and that therefore contrast is driven solely by changes in venous oxygen saturation. Recent evidence has emerged from rodent studies indicating that precapillary arterioles may have an oxygenation level as low as 78%. Here, we assess arterial oxygenation in vivo in humans by using short inversion time ASL in normoxia, as well as hyperoxia. Our results suggest that imaging the BOLD response may not be affected by partially oxygenated arterioles.

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