Abstract #1716

Flow Related Changes in Oxygen Extraction Fraction Detected using Streamlined-qBOLD

Alan J Stone¹ and Nicholas P Blockley¹

¹FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

In this study we investigate the sensitivity of streamlined-qBOLD for detecting changes in baseline brain oxygenation and therefore its suitability for clinical application to vascular dysfunction and stroke. Baseline brain oxygenation is modulated in a group of normal volunteers using hypocapnia (a reduction in blood CO₂). In this group, streamlined-qBOLD measured significant (p<0.05) increases in grey matter R₂′ and OEF, between normocapnic and hypocapnic conditions. This suggests the technique can provide important metabolic information in cases of vascular dysfunction where flow and brain oxygenation may be impaired.

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