Meeting Banner
Abstract #1716

Flow Related Changes in Oxygen Extraction Fraction Detected using Streamlined-qBOLD

Alan J Stone1 and Nicholas P Blockley1

1FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

In this study we investigate the sensitivity of streamlined-qBOLD for detecting changes in baseline brain oxygenation and therefore its suitability for clinical application to vascular dysfunction and stroke. Baseline brain oxygenation is modulated in a group of normal volunteers using hypocapnia (a reduction in blood CO2). In this group, streamlined-qBOLD measured significant (p<0.05) increases in grey matter R2′ and OEF, between normocapnic and hypocapnic conditions. This suggests the technique can provide important metabolic information in cases of vascular dysfunction where flow and brain oxygenation may be impaired.

This abstract and the presentation materials are available to members only; a login is required.

Join Here