Abstract #1720

High-Resolution CMRO2 Mapping During a Unilateral Pinch-Force Task

Maria Guidi¹, Christopher J. Steele¹, Laurentius Huber², Leonie Lampe¹, Viola Rjosk¹, Pierre-Louis Bazin¹, and Harald E. Möller¹

¹Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ²NIMH, Bethesda, MD, United States

Motor tasks have been extensively studied with BOLD fMRI. The way the BOLD response scales with task intensity level might come from an increased metabolic activity as well as an increased CBF and CBV. In this study, we aimed at disentangling such contributions combining a gas manipulation session with a pinch-task with simultaneous recording of force values. This way, the Davis model for calibration of fMRI could be applied and the oxygen metabolism changes estimated at every timestep. BOLD signal changes, VASO signal changes, and CMRO₂ changes were shown to weakly scale with the intensity of the pinch-force task.

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