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Abstract #1721

Is the local functional connectivity anisotropy (LFCA) in white matter caused by neuro-electric activity?  An examination of potential confounds for orientation-dependent LFCA in fMRI

Michael J. Tobia1, David Gallagher1, Rahul Dewal1, Sebastien Rupprecht1, Prasanna Karunanayaka1, and Qing X. Yang1

1Radiology, Penn State Hershey, Hershey, PA, United States

Phantom experiments showed that fluctuating electric current is sufficient to generate local functional connectivity anisotropy (LFCA), and that effects of motion, such as Lorentz forces, cannot explain the alignment of eigenvectors through neighboring voxels or B0 orientation-dependence. In conclusion, anisotropic correlations of fMRI time series may arise from an alternative non-BOLD contrast mechanism, potentially related to an electric current effect on B0.

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