Abstract #1728

The influence of multi-band acquisition on multiscale entropy derived from resting state BOLD

Charles B Malpas^1,2, Tim Silk³, and Marc Seal³

¹Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, ²Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Melbourne, Australia, ³Murdoch Children's Research Institute, Melbourne, Australia

Multi-scale entropy (MSE) quantifies the complexity of a time-series. Regular, predictable time-series have low MSE, while random time-series have high MSE. In this study, we compared conventional and multi-band acquisitions of resting-state BOLD images to determine their impact on MSE. We found that multi-band acquisitions produced lower MSE compared to non-multi-band acquisition. The effect did not persist when the number of volumes acquired was taken into consideration, suggesting that it is the number of volumes, and not multi-band acquisition per se that influences MSE. The implications for biomarker use are discussed, with particular emphasis on the ageing brain.

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