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Abstract #1728

The influence of multi-band acquisition on multiscale entropy derived from resting state BOLD

Charles B Malpas1,2, Tim Silk3, and Marc Seal3

1Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, 2Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Melbourne, Australia, 3Murdoch Children's Research Institute, Melbourne, Australia

Multi-scale entropy (MSE) quantifies the complexity of a time-series. Regular, predictable time-series have low MSE, while random time-series have high MSE. In this study, we compared conventional and multi-band acquisitions of resting-state BOLD images to determine their impact on MSE. We found that multi-band acquisitions produced lower MSE compared to non-multi-band acquisition. The effect did not persist when the number of volumes acquired was taken into consideration, suggesting that it is the number of volumes, and not multi-band acquisition per se that influences MSE. The implications for biomarker use are discussed, with particular emphasis on the ageing brain.

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