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Abstract #1729

Patterns of gray matter alterations in first episode manic adolescents

Li Yao1, Wenjing Zhang1, Yuan Xiao1, Wade Weber2, Christina Klein2, Rodrigo Patino 2, Qiyong Gong1, Melissa DelBello2, Su Lui1, and Caleb Adler2

1Huaxi MR Reasearch Center, Chengdu, China, People's Republic of, 2Department of Psychiatry and Behavioral Neuroscience, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH, United States

Gray matter volume and cortical thickness was measured to investigate the anatomical deficit in bipolar patients with severe mania. 60 patients and 29 healthy controls were recruited. Whole brain grey matter volume and cortical thickness measurements were extracted from T1-weighted MRI images and agglomerative hierarchical clustering was performed to subgroup the patients. The grey matter reduction and cortical thinning may underlie affective processing and cognition impairments in patients. In addition, the homogeneous patterns of brain deficits support the manic bipolar patients as a disease with mostly the same pattern of cerebral changes.

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