Li Yao1, Wenjing Zhang1, Yuan Xiao1, Wade Weber2, Christina Klein2, Rodrigo Patino 2, Qiyong Gong1, Melissa DelBello2, Su Lui1, and Caleb Adler2
1Huaxi MR Reasearch Center, Chengdu, China, People's Republic of, 2Department of Psychiatry and Behavioral Neuroscience, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH, United States
Gray matter volume and cortical thickness was measured
to investigate the anatomical deficit in bipolar patients with severe mania. 60
patients and 29 healthy controls were recruited. Whole brain grey matter volume
and cortical thickness measurements were extracted from T1-weighted MRI images
and agglomerative hierarchical clustering was performed to subgroup the
patients. The grey matter reduction and cortical thinning may underlie
affective processing and cognition impairments in patients. In addition, the homogeneous
patterns of brain deficits support the manic bipolar patients as a disease with
mostly the same pattern of cerebral changes.
