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Abstract #1734

Temporal homogeneity in BOLD time-series: an application to Rolandic epilepsy

Lalit Gupta1, Jacobus FA Jansen2, René MH Besseling2, Anton de Louw3, Albert P Aldenkamp3, and Walter H Backes2

1Philips India Ltd., Bangalore, India, 2Department of Radiology, Maastricht University Medical Center, Maastricht, Netherlands, 3Epilepsy Center Kempenhaeghe, Heeze, Netherlands

We present a novel method that yields a “temporal homogeneity measure” (TeHo), which captures temporal characteristics of the Blood-Oxygen-Level-Dependent (BOLD) time-series in terms of the average decrease in wavelet energy entropy (WEE) as a function of frequency. As an application we have analyzed cerebral abnormalities in the temporal fluctuations of children with Rolandic epilepsy. Results on 22 patients and 22 controls show that the TeHo method is sensitive to detect abnormal BOLD fluctuations in the brains’ of children with Rolandic epilepsy. These patients showed reduced TeHo, which indicates an altered frequency structure due to the epilepsy.

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