Abstract #1736

BOLD-fMRI signal changes during prolonged heat pain stimulation

Marianne Cleve¹, Alexander Gussew¹, and Jürgen R. Reichenbach¹

¹Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany

We performed five BOLD-fMRI measurements in healthy volunteers during prolonged heat pain stimulation to investigate the consistency of brain region specific activation and temporal alterations of brain activation. Left and right insula showed pain related activation in all volunteers and the highest activation values in the left insula at the beginning of the experiment. Compared to the insular regions, ACC and precuneus revealed higher BOLD signal variations during 11 min of noxious stimulation. The findings can be interpreted as region specific habituation effects on pain processing in the human brain.

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