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Abstract #1743

Calibration, validation, and sensitivity analysis of a 3D method for the mapping of brain venous oxygenation

Deng Mao1,2, Yang Li1, Peiying Liu1, Shin-Lei Peng3, and Hanzhang Lu1

1Russell H. Morgan Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Graduate School of Biomedical Sciences, Univ of Texas Southwestern Medical Center, Dallas, TX, United States, 3Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan

The present study aimed to further develop and investigate of a non-invasive, efficient and reproducible technique to map brain venous oxygenation in 3D. We first improved the processing pipeline by substracting angiogram to remove arterial content and apply threholdings to eliminate poor fitted and low signal voxels. We then calibrated T2* to oxygenation relationship in vitro using the same technique. In addition, we used hyperoxia challenge to test its sensitivity and combined TRUST MRI method for validation.

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