Abstract #1744

High correlation of VasA and vascular reactivity M supports vascular origin of VasA

Samira M Kazan¹, Laurentius Huber², Guillaume Flandin¹, Peter Bandettini², and Nikolaus Weiskopf^1,3

¹Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom, ²Functional Imaging Methods Laboratory of Brain, National Institute of Mental Health, Washington, DC, United States, ³Department of Neurophysics, Max Planck Institute for Human Cognition and Brain Sciences, Leipzig, Germany

We recently presented a vascular autocalibration method (VasA) to account for vascularization differences between subjects and hence improve the sensitivity in group studies. Here, we validate the novel calibration method by means of direct comparisons of VasA with the established measure of vascular reactivity, the M-value, obtained during induced hypercapnia. We show strong evidence that VasA is dominated by local vascular reactivity variations similarly to the M-value. We conclude that the VasA calibration method is an adequate tool for application in group studies to help increasing the statistical significance and reflects to a large degree local vascularization.

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