Abstract #1750

Resting-state fMRI as a tool for evaluating level of anesthesia and BOLD fMRI response in anesthetized rats

Jaakko Paasonen¹, Raimo A Salo¹, Joanna K Huttunen¹, and Olli Gröhn¹

¹Department of Neurobiology, University of Eastern Finland, Kuopio, Finland

Anesthesia is a major confounding factor in fMRI studies, because it directly affects brain function. As recent evidence suggests that functional connectivity (FC) changes with anesthetic depth, we investigated whether FC could be used to measure anesthetic depth in preclinical fMRI studies and subsequently predict fMRI responses under five anesthetics. The FC was able to predict the magnitude of fMRI responses under different anesthetics. The FC also changed during 1-h interval with injectable anesthetics. Therefore, we conclude that FC analysis of baseline fMRI data can provide simple way to control one of the key confounding factors in preclinical fMRI studies.

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