Abstract #1755

Reproducibility of cerebral sensorimotor activation in functional magnetic resonance imaging in isoflurane-anesthetized rats : A test-retest effect

Won Beom Jung¹, Ji Hoon Cha¹, Geun Ho Im², Sun Young Chae³, and Jung Hee Lee¹

¹Department of Radiology, Samsung Medical Center, Seoul, Korea, Republic of, ²Center for Molecular and cellular imaging, Samsung Biomedical Research Institute, Seoul, Korea, Republic of, ³Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea, Republic of

Blood oxygen level dependent (BOLD)-functional magnetic resonance imaging (fMRI) technique for rats is an emerging field in neuroscience. Inhalation anesthetics are often used for longitudinal fMRI experiments of rodent. Confirming the degree of reproducibility for stimulation induced fMRI response is especially important on longitudinal studies when investigating a time course of functional recovery. In this study, we evaluated the reproducibility or time-dependent changes of fMRI activation in somatosensory cortex in rats under isoflurane anesthesia.

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