Abstract #1812

The Harmonized Human Connectome Protocol for Multi-Site Brain MRI Studies

Joshua M Kuperman¹, Nathan S White¹, Hauke Bartsch¹, Matthew Middione², Kun Lu³, Thomas Liu³, Terry Jernigan⁴, Ajit Shankaranarayanan², and Anders M Dale^1,5

¹Radiology, University of California, San Diego, La Jolla, CA, United States, ²GE Healthcare, Menlo Park, CA, United States, ³Center for Functional Magnetic Resonance Imaging, University of California, San Diego, La Jolla, CA, United States, ⁴Center for Human Development, University of California, San Diego, La Jolla, CA, United States, ⁵Neurosciences, University of California, San Diego, La Jolla, CA, United States

The benefits of the advanced MRI protocols used in the Human Connectome Project have heretofore only been available on Siemens MRI scanners. We have designed a Connectome-like protocol, called the Harmonized Human Connectome Protocol, which can utilize MRI scanners from additional vendors, specifically GE and Philips. This protocol is particularly relevant for the Adolescent Brain and Cognitive Development Study, which aims to scan over 10,000 children ages 9-10 and follow them longitudinally for ten years. This abstract details the protocol for the GE MR750 scanner and outlines calibration and correction procedures which can be used to further reduce unwanted site/scanner effects.

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