Abstract #1813

Retrospective self-gated 3D UTE MRI in the mouse lung

Jinbang Guo^1,2, Xuefeng Cao^1,3, Zackary I. Cleveland¹, and Jason C. Woods^1,2

¹Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ²Physics, Washington University in St. Louis, St. Louis, MO, United States, ³Department of Physics, University of Cincinnati, Cincinnati, OH, United States

Motion due to respiration is one of the major difficulties in lung imaging of mice, which have a 10-20-fold higher respiratory rate than humans. In this study, we demonstrate that the FID signal amplitude (k = 0) as a function of projection number in center-out radial 3D UTE reflects respiratory motion. Retrospective "self"-gating using this FID signal amplitude was applied to extract data for end-expiration and end-inspiration respectively. Quantitative analysis of tidal volumes and lung parenchymal signal match external measurements and physiological expectations.

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