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Abstract #1813

Retrospective self-gated 3D UTE MRI in the mouse lung

Jinbang Guo1,2, Xuefeng Cao1,3, Zackary I. Cleveland1, and Jason C. Woods1,2

1Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Physics, Washington University in St. Louis, St. Louis, MO, United States, 3Department of Physics, University of Cincinnati, Cincinnati, OH, United States

Motion due to respiration is one of the major difficulties in lung imaging of mice, which have a 10-20-fold higher respiratory rate than humans. In this study, we demonstrate that the FID signal amplitude (k = 0) as a function of projection number in center-out radial 3D UTE reflects respiratory motion. Retrospective "self"-gating using this FID signal amplitude was applied to extract data for end-expiration and end-inspiration respectively. Quantitative analysis of tidal volumes and lung parenchymal signal match external measurements and physiological expectations.

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