Abstract #1823

In Vivo Feasibility of Multi-Parametric Mapping Based on Fast Steady-State Sequences

Ludovic de Rochefort¹, Geneviève Guillot¹, Rose-Marie Dubuisson¹, and Romain Valabrègue²

¹Imagerie par résonance magnétique médicale et multi-modalités, IR4M, UMR 8081, CNRS-Université Paris-Sud, Université Paris-Saclay, Orsay, France, ²CENIR, ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127F, Paris, France

Fast steady-state sequences combine RF and gradient spoiling to modulate contrasts in MRI. The steady-state depends on many physical and acquisition parameters. Here, in vivo feasibility on brain is shown to map proton density, background phase, flip angle, relaxation rates and apparent diffusion coefficient from such sequences. Multiple volumes were acquired with various optimized prescribed flip angle, spoiling gradients and phase increments, and the complex signal was fitted to the Bloch-Torrey signal model with free diffusion using efficient calculation algorithms. The acquisition of full 3D co-localized multi-parametric maps of relevant MR physical parameters in a realistic scan time is demonstrated.

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