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Abstract #1824

Dynamic pH quantification from spectrally selective 31P MRI in exercising skeletal muscle

Albrecht Ingo Schmid1,2, Martin Meyerspeer1,2, Simon Daniel Robinson2,3, Martin Krssak2,3,4, Michael Wolzt5, Ewald Moser1,2, and Ladislav Valkovic2,3

1Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 2MR Centre of Excellence, Medical University of Vienna, Vienna, Austria, 3Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 4Department of Internal Medicine 3, Medical University of Vienna, Vienna, Austria, 5Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

MR spectroscopy provides valuable information about tissue metabolism but suffers from slow acquisition or poor spatial resolution and coverage. PCr and pH kinetics are the two important quantities derived from 31P MR data. MRI has been used to measure PCr in the past, but not pH. Simultaneous fast 3-D gradient-echo images of PCr and Pi were acquired in healthy volunteers at 7T during exercise recovery. pH was calculated from phase images. Results of PCr and pH kinetics are comparable to MRS data. In conclusion, 31P MRI is an alternative to 31P MRS for fast coverage of multiple ROIs and low SAR.

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