Abstract #1824

Dynamic pH quantification from spectrally selective 31P MRI in exercising skeletal muscle

Albrecht Ingo Schmid^1,2, Martin Meyerspeer^1,2, Simon Daniel Robinson^2,3, Martin Krssak^2,3,4, Michael Wolzt⁵, Ewald Moser^1,2, and Ladislav Valkovic^2,3

¹Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, ²MR Centre of Excellence, Medical University of Vienna, Vienna, Austria, ³Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ⁴Department of Internal Medicine 3, Medical University of Vienna, Vienna, Austria, ⁵Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

MR spectroscopy provides valuable information about tissue metabolism but suffers from slow acquisition or poor spatial resolution and coverage. PCr and pH kinetics are the two important quantities derived from ³¹P MR data. MRI has been used to measure PCr in the past, but not pH. Simultaneous fast 3-D gradient-echo images of PCr and P_i were acquired in healthy volunteers at 7T during exercise recovery. pH was calculated from phase images. Results of PCr and pH kinetics are comparable to MRS data. In conclusion, ³¹P MRI is an alternative to ³¹P MRS for fast coverage of multiple ROIs and low SAR.

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