Dietmar Cordes1,2, Zhengshi Yang1, Xiaowei Zhuang1, Karthik Sreenivasan1, and Le Hanh Hua1
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, United States
In this study, a new algorithm to better model the
receiver coil sensitivities with the purpose of obtaining unbiased proton
density maps is proposed. Using optimized orthonormal basis functions for the
modeling produces an accurate fit of potential inhomogeneities of the signal
due to receiver coil bias. The obtained final image of the proton density has
low variance, suitable for quantitative diagnostic information of brain tissue.
Results are shown for nine MS patients and one control subject.