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Abstract #1897

Multidimensional Diffusion and Relaxation Data Acquisition for Improved Intravoxel Incoherent Motion Analysis

Anna Scherman Rydhög1, André Ahlgren1, Freddy Ståhlberg1,2,3, Ronnie Wirestam1, and Linda Knutsson1

1Department of Medical Radiation Physics, Lund University, Lund, Sweden, 2Department of Diagnostic Radiology, Lund University, Lund, Sweden, 3Lund Bioimaging Center, Lund University, Lund, Sweden

Intravoxel Incoherent Motion (IVIM) is a method for quantification of perfusion parameters, such as the perfusion fraction Fb. Unfortunately, CSF partial volume effects are often seen in the estimated blood compartment. This work introduces a novel version of the IVIM model, containing three compartments (tissue, CSF and blood), where multi-TE and multi-TI data are incorporated to yield a direct relaxation estimate. Using this relaxation-compensated model, results were obtained from in vivo measurements in a volunteer. Compared to a non-relaxation-compensated model, the three-compartment model with relaxation-compensated data reduced the CSF contamination.

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