Abstract #1897

Multidimensional Diffusion and Relaxation Data Acquisition for Improved Intravoxel Incoherent Motion Analysis

Anna Scherman Rydhög¹, André Ahlgren¹, Freddy Ståhlberg^1,2,3, Ronnie Wirestam¹, and Linda Knutsson¹

¹Department of Medical Radiation Physics, Lund University, Lund, Sweden, ²Department of Diagnostic Radiology, Lund University, Lund, Sweden, ³Lund Bioimaging Center, Lund University, Lund, Sweden

Intravoxel Incoherent Motion (IVIM) is a method for quantification of perfusion parameters, such as the perfusion fraction Fb. Unfortunately, CSF partial volume effects are often seen in the estimated blood compartment. This work introduces a novel version of the IVIM model, containing three compartments (tissue, CSF and blood), where multi-TE and multi-TI data are incorporated to yield a direct relaxation estimate. Using this relaxation-compensated model, results were obtained from in vivo measurements in a volunteer. Compared to a non-relaxation-compensated model, the three-compartment model with relaxation-compensated data reduced the CSF contamination.

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